Abnormal Behavior in a Chromosome- Engineered Mouse Model for Human 15q11-13 Duplication Seen in Autism

Substantial evidence suggests that chromosomal abnormalities contribute to the risk of autism. The duplication of human chromosome 15q11-13 is known to be the most frequent cytogenetic abnormality in autism. We have modeled this genetic change in mice by using chromosome engineering to generate a 6....

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Autors principals: Nakatani, Jin, Tamada, Kota, Hatanaka, Fumiyuki, Ise, Satoko, Ohta, Hisashi, Inoue, Kiyoshi, Tomonaga, Shozo, Watanabe, Yasuhito, Chung, Yeun Jun, Banerjee, Ruby, Iwamoto, Kazuya, Kato, Tadafumi, Okazawa, Makoto, Yamauchi, Kenta, Tanda, Koichi, Takao, Keizo, Miyakawa, Tsuyoshi, Bradley, Allan, Takumi, Toru
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710970/
https://ncbi.nlm.nih.gov/pubmed/19563756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.04.024
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