Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy

Osteosarcoma (OS) is one of the most common malignant bone tumors in early adolescence. Multi-drug chemotherapy has greatly increased the five year survival rate from 20% to 70%. However, the rate has been staggering for 30 years and the prognosis is particularly poor for patients with recurrence an...

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Autori principali: Ma, Yimin, Ren, Yongxin, Han, Ethan Q., Li, Huiwu, Chen, Di, Jacobs, Joshua J., Gitelis, Steven, O’Keefe, Regis J., Konttinen, Yrjö T., Yin, Guoyong, Li, Tian-Fang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3710725/
https://ncbi.nlm.nih.gov/pubmed/23291185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2012.12.118
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