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High-Resolution Phylogenetic Analysis of Hepatitis C Virus Adaptation and Its Relationship to Disease Progression

Hepatitis C virus (HCV) persists in the majority of those infected despite host immune responses. Evidence has accrued that selectively fixed mutations in the envelope genes (E1 and E2) are associated with viral persistence, particularly those that occur within the first hypervariable region of E2 (...

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Detalhes bibliográficos
Main Authors: Sheridan, Isabelle, Pybus, Oliver G., Holmes, Edward C., Klenerman, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC371055/
https://ncbi.nlm.nih.gov/pubmed/15016867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.7.3447-3454.2004
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