Insights into Diphthamide, Key Diphtheria Toxin Effector

Diphtheria toxin (DT) inhibits eukaryotic translation elongation factor 2 (eEF2) by ADP-ribosylation in a fashion that requires diphthamide, a modified histidine residue on eEF2. In budding yeast, diphthamide formation involves seven genes, DPH1-DPH7. In an effort to further study diphthamide synthe...

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Bibliographic Details
Main Authors: Abdel-Fattah, Wael, Scheidt, Viktor, Uthman, Shanow, Stark, Michael J. R., Schaffrath, Raffael
Format: Artigo
Language:Inglês
Published: MDPI 2013
Subjects:
Brief Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709272/
https://ncbi.nlm.nih.gov/pubmed/23645155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins5050958
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