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On the Origins of Mendelian Disease Genes in Man: The Impact of Gene Duplication
Over 3,000 human diseases are known to be linked to heritable genetic variation, mapping to over 1,700 unique genes. Dating of the evolutionary age of these disease-associated genes has suggested that they have a tendency to be ancient, specifically coming into existence with early metazoa. The appr...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3709195/ https://ncbi.nlm.nih.gov/pubmed/21705381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msr111 |
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