Prevention of doxorubicin cardiac toxicity in the mouse by N-acetylcysteine.

This study was undertaken to investigate the effect of exogenous sulfhydryl compound administration on the toxicity of doxorubicin in mice. Pretreatment of CDF1 mice with a pharmacologic dose (2,000 mg/kg) of n-acetyl-l-cysteine 1 h before doxorubicin (20 mg/kg, i.p.) decreased lethality from 100% (...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Doroshow, J H, Locker, G Y, Ifrim, I, Myers, C E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1981
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370893/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7287901/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110328
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