Irf8-Regulated Genomic Responses Drive Pathological Inflammation during Cerebral Malaria

Interferon Regulatory Factor 8 (IRF8) is required for development, maturation and expression of anti-microbial defenses of myeloid cells. BXH2 mice harbor a severely hypomorphic allele at Irf8 (Irf8(R294C)) that causes susceptibility to infection with intracellular pathogens including Mycobacterium...

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Autores principales: Berghout, Joanne, Langlais, David, Radovanovic, Irena, Tam, Mifong, MacMicking, John D., Stevenson, Mary M., Gros, Philippe
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708918/
https://ncbi.nlm.nih.gov/pubmed/23853600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003491
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