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Irf8-Regulated Genomic Responses Drive Pathological Inflammation during Cerebral Malaria
Interferon Regulatory Factor 8 (IRF8) is required for development, maturation and expression of anti-microbial defenses of myeloid cells. BXH2 mice harbor a severely hypomorphic allele at Irf8 (Irf8(R294C)) that causes susceptibility to infection with intracellular pathogens including Mycobacterium...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3708918/ https://ncbi.nlm.nih.gov/pubmed/23853600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003491 |
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