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Fine tuning endothelial Notch: SIRT-ainly an unexpected mechanism
Guarini et al. (2011), reporting in Nature, identify a mechanism for fine-tuning endothelial Notch signaling by SIRT1-mediated deacetylation. This regulation is critical for vascular sprouting and raises intriguing questions about therapeutic targeting of SIRT1 in angiogenesis and the potential mech...
Kaydedildi:
| Yazar: | |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3708663/ https://ncbi.nlm.nih.gov/pubmed/21571214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2011.05.001 |
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