Constitutive CD40L Expression on B Cells Prematurely Terminates Germinal Center Response and Leads to Augmented Plasma Cell Production in T Cell Areas

CD40/CD40L engagement is essential to T cell-dependent B cell proliferation and differentiation. However, the precise role of CD40 signaling through cognate T–B interaction in the generation of germinal center and memory B cells is still incompletely understood. To address this issue, a B cell-speci...

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Bibliographic Details
Main Authors: Bolduc, Anna, Long, Eugene, Stapler, Dale, Cascalho, Marilia, Tsubata, Takeshi, Koni, Pandelakis A., Shimoda, Michiko
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3708602/
https://ncbi.nlm.nih.gov/pubmed/20505142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901689
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