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Reduction of Aromatic and Heterocyclic Aromatic N-Hydroxylamines by Human Cytochrome P450 2S1

Many aromatic amines and heterocyclic aromatic amines (HAAs) are known carcinogens for animals and there is also strong evidence for some in human cancer. The activation of these compounds, including some arylamine drugs, involves N-hydroxylation, usually by cytochrome P450 enzymes (P450) in Family...

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Detalhes bibliográficos
Main Authors: Wang, Kai, Guengerich, F. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707514/
https://ncbi.nlm.nih.gov/pubmed/23682735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx400139p
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