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Synthesis of 2′-N-Methylamino-2′-deoxyguanosine and 2′-N,N-Dimethylamino-2′-deoxyguanosine and Their Incorporation into RNA by Phosphoramidite Chemistry

[Image: see text] The 2′-hydroxyl groups within RNA contribute in essential ways to RNA structure and function. Previously, we designed an atomic mutation cycle (AMC) that uses ribonucleoside analogues bearing different C-2′-substituents, including −OCH(3), −NH(2), −NHMe, and −NMe(2), to identify hy...

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Hlavní autoři: Dai, Qing, Sengupta, Raghuvir, Deb, Shirshendu K., Piccirilli, Joseph A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707316/
https://ncbi.nlm.nih.gov/pubmed/21942326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo201364x
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