Effects of ML-236B (Compactin) on Sterol Synthesis and Low Density Lipoprotein Receptor Activities in Fibroblasts of Patients with Homozygous Familial Hypercholesterolemia

We studied biochemical genetics of low density lipoprotein (LDL) receptor mutations in fibroblasts from six homozygous and five heterozygous patients with familial hypercholesterolemia (FH). Three of six homozygotes are receptor-negative type and the other three homozygotes are receptor-defective ty...

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Hoofdauteurs: Haba, Toshihiro, Mabuchi, Hiroshi, Yoshimura, Akira, Watanabe, Akira, Wakasugi, Takanobu, Tatami, Ryozo, Ueda, Kosei, Ueda, Ryosei, Kametani, Tomio, Koizumi, Junji, Miyamoto, Susumu, Takeda, Ryoyu, Takeshita, Haruo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 1981
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC370722/
https://ncbi.nlm.nih.gov/pubmed/7229037
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