Myostatin genetic inactivation inhibits myogenesis by muscle-derived stem cells in vitro but not when implanted in the mdx mouse muscle

INTRODUCTION: Stimulating the commitment of implanted dystrophin+ muscle-derived stem cells (MDSCs) into myogenic, as opposed to lipofibrogenic lineages, is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD). METHODS: To examine whether counteracting myostatin, a negative regulat...

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Autores principales: Tsao, James, Vernet, Dolores A, Gelfand, Robert, Kovanecz, Istvan, Nolazco, Gaby, Bruhn, Kevin W, Gonzalez-Cadavid, Nestor F
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706886/
https://ncbi.nlm.nih.gov/pubmed/23295128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/scrt152
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