Genes and pathways underlying regional and cell type changes in Alzheimer's disease

BACKGROUND: Transcriptional studies suggest Alzheimer's disease (AD) involves dysfunction of many cellular pathways, including synaptic transmission, cytoskeletal dynamics, energetics, and apoptosis. Despite known progression of AD pathologies, it is unclear how such striking regional vulnerabi...

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Autori principali: Miller, Jeremy A, Woltjer, Randall L, Goodenbour, Jeff M, Horvath, Steve, Geschwind, Daniel H
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706780/
https://ncbi.nlm.nih.gov/pubmed/23705665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm452
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