Genes and pathways underlying regional and cell type changes in Alzheimer's disease

BACKGROUND: Transcriptional studies suggest Alzheimer's disease (AD) involves dysfunction of many cellular pathways, including synaptic transmission, cytoskeletal dynamics, energetics, and apoptosis. Despite known progression of AD pathologies, it is unclear how such striking regional vulnerabi...

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Detalhes bibliográficos
Main Authors: Miller, Jeremy A, Woltjer, Randall L, Goodenbour, Jeff M, Horvath, Steve, Geschwind, Daniel H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706780/
https://ncbi.nlm.nih.gov/pubmed/23705665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm452
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