Effects of Nasal or Pulmonary Delivered Treatments with an Adenovirus Vectored Interferon (mDEF201) on Respiratory and Systemic Infections in Mice Caused by Cowpox and Vaccinia Viruses

An adenovirus 5 vector encoding for mouse interferon alpha, subtype 5 (mDEF201) was evaluated for efficacy against lethal cowpox (Brighton strain) and vaccinia (WR strain) virus respiratory and systemic infections in mice. Two routes of mDEF201 administration were used, nasal sinus (5-µl) and pulmon...

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Bibliographic Details
Main Authors: Smee, Donald F., Wong, Min-Hui, Hurst, Brett L., Ennis, Jane, Turner, Jeffrey D.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706414/
https://ncbi.nlm.nih.gov/pubmed/23874722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068685
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