A novel variant of human SOD1 harboring ALS-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo

Mutations in SOD1 cause FALS. The Cu binding capacity of SOD1 has spawned hypotheses that implicate metal-mediated production of reactive species as a potential mechanism of toxicity. In past experiments, we have tested such hypotheses by mutating residues in SOD1 that normally coordinate the bindin...

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Bibliographic Details
Main Authors: Prudencio, Mercedes, Lelie, Herman, Brown, Hilda H., Whitelegge, Julian P., Valentine, Joan S., Borchelt, David R.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705958/
https://ncbi.nlm.nih.gov/pubmed/22332887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07690.x
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