Susceptibility for Lupus Nephritis by Low Copy Number of the FCGR3B Gene Is Linked to Increased Levels of Pathogenic Autoantibodies

Low copy number (CN) of the FCGR3B gene reduces FCGR3B membrane expression on neutrophils and results in clearance of a smaller amount of immune complex. We investigated FCGR3B CN in relation to the clinical phenotype in a Caucasian SLE cohort (n = 107). FCGR3B CN was determined by three different q...

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Bibliografiske detaljer
Main Authors: Nossent, Johannes C., Becker-Merok, Andrea, Rischmueller, Maureen, Lester, Sue
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705838/
https://ncbi.nlm.nih.gov/pubmed/23864940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/750814
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