ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice

ProNGF, the precursor of mature nerve growth factor (NGF), is the most abundant form of NGF in the brain. ProNGF and mature NGF differ significantly in their receptor interaction properties and in their bioactivity. ProNGF increases markedly in the cortex of Alzheimer's disease (AD) brains and...

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Main Authors: Tiveron, C, Fasulo, L, Capsoni, S, Malerba, F, Marinelli, S, Paoletti, F, Piccinin, S, Scardigli, R, Amato, G, Brandi, R, Capelli, P, D'Aguanno, S, Florenzano, F, La Regina, F, Lecci, A, Manca, A, Meli, G, Pistillo, L, Berretta, N, Nisticò, R, Pavone, F, Cattaneo, A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705592/
https://ncbi.nlm.nih.gov/pubmed/23538417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.22
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