ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice

ProNGF, the precursor of mature nerve growth factor (NGF), is the most abundant form of NGF in the brain. ProNGF and mature NGF differ significantly in their receptor interaction properties and in their bioactivity. ProNGF increases markedly in the cortex of Alzheimer's disease (AD) brains and...

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Bibliografski detalji
Glavni autori: Tiveron, C, Fasulo, L, Capsoni, S, Malerba, F, Marinelli, S, Paoletti, F, Piccinin, S, Scardigli, R, Amato, G, Brandi, R, Capelli, P, D'Aguanno, S, Florenzano, F, La Regina, F, Lecci, A, Manca, A, Meli, G, Pistillo, L, Berretta, N, Nisticò, R, Pavone, F, Cattaneo, A
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2013
Teme:
Original Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705592/
https://ncbi.nlm.nih.gov/pubmed/23538417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.22
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