Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis

The tumor suppressor gene p53 has been implicated in the regulation of epithelial–mesenchymal transition (EMT) and tumor metastasis by regulating microRNA (miRNA) expression. Here, we report that mutant p53 exerts oncogenic functions and promotes EMT in endometrial cancer (EC) by directly binding to...

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Detalhes bibliográficos
Main Authors: Dong, P, Karaayvaz, M, Jia, N, Kaneuchi, M, Hamada, J, Watari, H, Sudo, S, Ju, J, Sakuragi, N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3705163/
https://ncbi.nlm.nih.gov/pubmed/22847613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.334
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