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A GCH1 Haplotype and Risk of Neural Tube Defects in the National Birth Defects Prevention Study
Tetrahydrobiopterin (BH(4)) is an essential cofactor and an important cellular antioxidant. BH(4) deficiency has been associated with diseases whose etiologies stem from excessive oxidative stress. GTP cyclohydrolase I (GCH1) catalyzes the first and rate-limiting step of de novo BH(4) synthesis. A 3...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3704723/ https://ncbi.nlm.nih.gov/pubmed/23059057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2012.09.020 |
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