Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Activation of mammalian target of rapamycin 1 (mTORC1) by nutrients, insulin and leptin leads to appetite suppression (anorexia). Contrastingly, increased AMP-activated protein kinase (AMPK) activity by ghrelin promotes appetite (orexia). However, the interplay between these mechanisms remains poorl...

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Detalhes bibliográficos
Main Authors: Watterson, Kenneth R., Bestow, Dawn, Gallagher, Jennifer, Hamilton, D. Lee, Ashford, Fiona B., Meakin, Paul J., Ashford, Michael L.J.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2012
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704126/
https://ncbi.nlm.nih.gov/pubmed/22456226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000334144
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