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Molecular mechanisms of multiple toxin–antitoxin systems are coordinated to govern the persister phenotype

Toxin–antitoxin systems are ubiquitous and have been implicated in persistence, the multidrug tolerance of bacteria, biofilms, and, by extension, most chronic infections. However, their purpose, apparent redundancy, and coordination remain topics of debate. Our model relates molecular mechanisms to...

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Detalhes bibliográficos
Main Authors: Fasani, Rick A., Savageau, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703989/
https://ncbi.nlm.nih.gov/pubmed/23781105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301023110
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