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In Silico Screening and Molecular Dynamics Simulation of Disease-Associated nsSNP in TYRP1 Gene and Its Structural Consequences in OCA3

Oculocutaneous albinism type III (OCA3), caused by mutations of TYRP1 gene, is an autosomal recessive disorder characterized by reduced biosynthesis of melanin pigment in the hair, skin, and eyes. The TYRP1 gene encodes a protein called tyrosinase-related protein-1 (Tyrp1). Tyrp1 is involved in main...

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מידע ביבליוגרפי
Main Authors: Kamaraj, Balu, Purohit, Rituraj
פורמט: Artigo
שפה:Inglês
יצא לאור: Hindawi Publishing Corporation 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703794/
https://ncbi.nlm.nih.gov/pubmed/23862152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/697051
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