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Alternative complement pathway activation increases mortality in a model of burn injury in mice.

We have studied the role of the complement system in burn injury in an experimental model in mice. A 25% body surface area, full-thickness scald wound was produced in anesthetized animals. Massive activation of the alternative complement pathway, but not the classical pathway, was seen. This activat...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Gelfand, J A, Donelan, M, Hawiger, A, Burke, J F
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1982
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370333/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7174787/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110715
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