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A semi-mechanistic absorption model to evaluate drug–drug interaction with dabigatran: application with clarithromycin
AIM: The aim of this study was to develop a PK/PD model to assess drug–drug interactions between dabigatran and P-gp modulators, using the example of clarithromycin, a strong inhibitor of P-gp. METHODS: Ten healthy male volunteers were randomized to receive in the first treatment period a single 300...
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| Główni autorzy: | , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Blackwell Science Inc
2013
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3703233/ https://ncbi.nlm.nih.gov/pubmed/23210726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12055 |
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