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Optimization and model reduction in the high dimensional parameter space of a budding yeast cell cycle model

BACKGROUND: Parameter estimation from experimental data is critical for mathematical modeling of protein regulatory networks. For realistic networks with dozens of species and reactions, parameter estimation is an especially challenging task. In this study, we present an approach for parameter estim...

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Detalhes bibliográficos
Main Authors: Oguz, Cihan, Laomettachit, Teeraphan, Chen, Katherine C, Watson, Layne T, Baumann, William T, Tyson, John J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702416/
https://ncbi.nlm.nih.gov/pubmed/23809412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-7-53
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