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Dual pH- and Temperature-responsive Microparticles for Protein Delivery to Ischemic Tissues

Injectable, “smart” microspheres that are sensitive to both temperature and pH have been fabricated and tested for controlled delivery of therapeutic proteins to ischemic skeletal muscle. A library of copolymers composed of N-isopropyl acrylamide (NIPAAm), propyl acrylic acid (PAA), and butyl acryla...

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Autors principals: Joshi, Rucha V., Nelson, Christopher E., Poole, Kristin M., Skala, Melissa C., Duvall, Craig L.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702271/
https://ncbi.nlm.nih.gov/pubmed/23402764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2013.01.041
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