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High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion

Vimentin is an intermediate filament protein, with a key role in the epithelial to mesenchymal transition as well as cell invasion, and it is often upregulated during cancer progression. However, relatively little is known about its regulation in cancer cells. Here, we performed an RNA interference...

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Detalhes bibliográficos
Main Authors: Lehtinen, Laura, Ketola, Kirsi, Mäkelä, Rami, Mpindi, John-Patrick, Viitala, Miro, Kallioniemi, Olli, Iljin, Kristiina
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702207/
https://ncbi.nlm.nih.gov/pubmed/23295955
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