Lentiviral Delivery of the Human Wild-type Tau Protein Mediates a Slow and Progressive Neurodegenerative Tau Pathology in the Rat Brain

Most models for tauopathy use a mutated form of the Tau gene, MAPT, that is found in frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) and that leads to rapid neurofibrillary degeneration (NFD). Use of a wild-type (WT) form of human Tau protein to model the aggregation and...

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Autors principals: Caillierez, Raphaëlle, Bégard, Séverine, Lécolle, Katia, Deramecourt, Vincent, Zommer, Nadège, Dujardin, Simon, Loyens, Anne, Dufour, Noëlle, Aurégan, Gwennaëlle, Winderickx, Joris, Hantraye, Philippe, Déglon, Nicole, Buée, Luc, Colin, Morvane
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702115/
https://ncbi.nlm.nih.gov/pubmed/23609018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.66
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