Development and characterization of a human single-chain antibody fragment against claudin-3: a novel therapeutic target in ovarian and uterine carcinomas

OBJECTIVE: The purpose of this study was to develop and characterize a human antibody in a single-chain antibody fragment format (scFv) that is directed specifically against claudin-3 (CLDN3). STUDY DESIGN: The synthetic ETH-2 Gold human antibody phage display library was used to select scFv specifi...

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Main Authors: Romani, Chiara, Comper, Fabrizio, Bandiera, Elisabetta, Ravaggi, Antonella, Bignotti, Eliana, Tassi, Renata A., Pecorelli, Sergio, Santin, Alessandro D.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701950/
https://ncbi.nlm.nih.gov/pubmed/19426958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajog.2009.02.010
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