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Monitoring Autophagy in the Treatment of Protein Aggregate Diseases: Steps Toward Identifying Autophagic Biomarkers
Neurodegenerative diseases such as Huntington disease, Parkinson’s disease, and Alzheimer’s disease are caused by the accumulation of aggregate prone proteins. Pathogenic proteins misfold, aggregate, and escape the cell’s normal degradative pathways. Protein aggregates subsequently lead to the toxic...
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| Главный автор: | |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Springer US
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3701771/ https://ncbi.nlm.nih.gov/pubmed/23408309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-013-0180-y |
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