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C-Reactive Protein Inhibits Plasmacytoid Dendritic Cell Interferon Responses to Autoantibody Immune Complexes
OBJECTIVE: CRP is a serum pattern recognition molecule that binds to apoptotic cells and nucleoprotein autoantigens and FcγR. In SLE IC containing nucleoprotein autoantigens activate plasmacytoid dendritic cells (pDC) to produce type I IFN, which contributes to disease pathogenesis. Autoantibody IC...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3701728/ https://ncbi.nlm.nih.gov/pubmed/23576062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.37968 |
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