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Budding Yeast Greatwall and Endosulfines Control Activity and Spatial Regulation of PP2A(Cdc55) for Timely Mitotic Progression

Entry into mitosis is triggered by cyclinB/Cdk1, whose activity is abruptly raised by a positive feedback loop. The Greatwall kinase phosphorylates proteins of the endosulfine family and allows them to bind and inhibit the main Cdk1-counteracting PP2A-B55 phosphatase, thereby promoting mitotic entry...

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書誌詳細
主要な著者: Juanes, Maria Angeles, Khoueiry, Rita, Kupka, Thomas, Castro, Anna, Mudrak, Ingrid, Ogris, Egon, Lorca, Thierry, Piatti, Simonetta
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701715/
https://ncbi.nlm.nih.gov/pubmed/23861665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003575
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