Myxoma Virus Protein M029 Is a Dual Function Immunomodulator that Inhibits PKR and Also Conscripts RHA/DHX9 to Promote Expanded Host Tropism and Viral Replication

Myxoma virus (MYXV)-encoded protein M029 is a member of the poxvirus E3 family of dsRNA-binding proteins that antagonize the cellular interferon signaling pathways. In order to investigate additional functions of M029, we have constructed a series of targeted M029-minus (vMyx-M029KO and vMyx-M029ID)...

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Bibliographic Details
Main Authors: Rahman, Masmudur M., Liu, Jia, Chan, Winnie M., Rothenburg, Stefan, McFadden, Grant
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701710/
https://ncbi.nlm.nih.gov/pubmed/23853588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003465
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