Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase, in healthy volunteers.

Mevinolin reduces cholesterol synthesis by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The safety and effectiveness of this agent was evaluated in a double-blind, placebo-controlled study in 59 healthy men (serum cholesterol 3.88--7.76 mmol/liter) in five centers. Subjects maintained...

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Udgivet i:J Clin Invest
Main Authors: Tobert, J A, Bell, G D, Birtwell, J, James, I, Kukovetz, W R, Pryor, J S, Buntinx, A, Holmes, I B, Chao, Y S, Bolognese, J A
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1982
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370145/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6918402/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110530
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