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Pharmacokinetics of Protein C and Antithrombin in the Fetal Lamb: A Model to Predict Human Neonatal Replacement Dosing

BACKGROUND: The preterm infant is at risk for consumptive coagulopathy and thrombosis due to late maturation of coagulation regulatory proteins. Replacement proteins are available, but neonatal pharmacokinetic data are lacking. OBJECTIVE: The objective was to determine the pharmacokinetic properties...

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Detalhes bibliográficos
Main Authors: Manco-Johnson, Marilyn J., Hacker, Michele R., Jacobson, Linda J., Hay, Jr., William W.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701438/
https://ncbi.nlm.nih.gov/pubmed/19039246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000178025
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