Exploration of an epoxidation–ring-opening strategy for the synthesis of lyconadin A and discovery of an unexpected Payne rearrangement

In the context of synthetic efforts targeting the alkaloid lyconadin A, scalemic epoxide 25 was prepared by a highly stereoselective sequence involving a Myers alkylation and a Shi epoxidation. Ring-opening of this epoxide with a vinylcopper complex afforded alcohol 26 instead of the expected produc...

Full description

Saved in:
Bibliographic Details
Main Authors: Loertscher, Brad M, Zhang, Yu, Castle, Steven L
Format: Artigo
Language:Inglês
Published: Beilstein-Institut 2013
Subjects:
Full Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701374/
https://ncbi.nlm.nih.gov/pubmed/23843911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.9.132
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items