Axon Guidance of Sympathetic Neurons to Cardiomyocytes by Glial Cell Line-Derived Neurotrophic Factor (GDNF)

Molecular signaling of cardiac autonomic innervation is an unresolved issue. Here, we show that glial cell line-derived neurotrophic factor (GDNF) promotes cardiac sympathetic innervation in vitro and in vivo. In vitro, ventricular myocytes (VMs) and sympathetic neurons (SNs) isolated from neonatal...

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Detalhes bibliográficos
Main Authors: Miwa, Keiko, Lee, Jong-Kook, Takagishi, Yoshiko, Opthof, Tobias, Fu, Xianming, Hirabayashi, Masumi, Watabe, Kazuhiko, Jimbo, Yasuhiko, Kodama, Itsuo, Komuro, Issei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701054/
https://ncbi.nlm.nih.gov/pubmed/23843937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065202
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