Prostacyclin and PPARα Agonists Control Vascular Smooth Muscle Cell Apoptosis and Phenotypic Switch through Distinct 14-3-3 Isoforms

We hypothesized that prostacyclin (PGI(2)) protects vascular smooth muscle cell (VSMC) against apoptosis and phenotypic switch through peroxisome proliferator-activated receptor-α (PPARα) activation and 14-3-3 upregulation. Here we showed that transfection of rat aortic VSMC, A-10, with PGI(2)-produ...

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Detalhes bibliográficos
Main Authors: Chen, Yen-Chung, Chu, Ling-Yun, Yang, Shu-Fan, Chen, Hua-Ling, Yet, Shaw-Fang, Wu, Kenneth K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701049/
https://ncbi.nlm.nih.gov/pubmed/23844263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069702
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