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Enhanced function of pancreatic islets co-encapsulated with ECM proteins and mesenchymal stromal cells in a silk hydrogel

Pancreatic islet encapsulation within biosynthetic materials has had limited clinical success due to loss of islet function and cell death. As an alternative encapsulation material, a silk-based scaffold was developed to reestablish the islet microenvironment lost during cell isolation. Islets were...

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Autores principales: Davis, Nicolynn E., Beenken-Rothkopf, Liese N., Mirsoian, Annie, Kojic, Nikola, Kaplan, David, Barron, Annelise E., Fontaine, Magali J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3701024/
https://ncbi.nlm.nih.gov/pubmed/22766242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.06.015
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