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Vagotomy Attenuates Brain Cytokines and Sleep Induced by Peripherally Administered Tumor Necrosis Factor-α and Lipopolysaccharide in Mice

STUDY OBJECTIVE: Systemic tumor necrosis factor-α (TNF-α) is linked to sleep and sleep altering pathologies in humans. Evidence from animals indicates that systemic and brain TNF-α have a role in regulating sleep. In animals, TNF-α or lipopolysaccharide (LPS) enhance brain pro-inflammatory cytokine...

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Main Authors: Zielinski, Mark R., Dunbrasky, Danielle L., Taishi, Ping, Souza, Gianne, Krueger, James M.
Format: Artigo
Sprog:Inglês
Udgivet: Associated Professional Sleep Societies, LLC 2013
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700720/
https://ncbi.nlm.nih.gov/pubmed/23904683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.2892
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