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Ezogabine (KCNQ2/3 channel opener) prevents delayed activation of meningeal nociceptors if given before but not after the occurrence of cortical spreading depression
We proposed recently that induction of delayed activation of trigeminovascular neurons by cortical spreading depression (CSD) can explain the delayed onset of headache after the aura. This prompted us to search for ways to block the neuronal activation by the CSD; a preclinical correlate of an attem...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3700644/ https://ncbi.nlm.nih.gov/pubmed/23562239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yebeh.2013.02.029 |
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