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Blockade of Programmed Death-1 (PD-1) in young (New Zealand Black × New Zealand White)F(1) mice promotes the suppressive capacity of CD4(+) regulatory T cells protecting from lupus-like disease
PD-1 usually acts as a negative signal for T cell activation, and its expression on CD8(+)Foxp3(+) T cells is required for their suppressive capacity. Here we show that PD-1 signalling is required for the maintenance of functional regulatory CD4(+)CD25(+)Foxp3(+)T cells (CD4(+)T(reg)) that can contr...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3700538/ https://ncbi.nlm.nih.gov/pubmed/23636058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202382 |
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