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Failure of a VapA/CpG oligodeoxynucleotide vaccine to protect foals against experimental Rhocococcus equi pneumonia despite induction of VapA-specific antibody and interferon-γ response

We evaluated the immunogenic and protective potential of a recombinant VapA/CpG oligodeoxynucleotide (ODN) 2395 vaccine in neonatal foals undergoing experimental Rhodococcus equi challenge. Foals (n = 8) were vaccinated by intramuscular injection on days 1 and 15 of the study; control foals (n = 7)...

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Bibliographische Detailangaben
Hauptverfasser: Lohmann, Katharina L., Lopez, A. Marianela, Manning, Stephen T., Marques, Fernando J., Brownlie, Robert, Allen, Andrew L., Sangster, Anna E., Mutwiri, George, Gerdts, Volker, Potter, Andrew, Townsend, Hugh G.G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Canadian Veterinary Medical Association 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700440/
https://ncbi.nlm.nih.gov/pubmed/24101791
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