Phosphorylation of Kaposi's Sarcoma-Associated Herpesvirus Processivity Factor ORF59 by a Viral Kinase Modulates Its Ability To Associate with RTA and oriLyt

ORF59 of Kaposi's sarcoma-associated herpesvirus (KSHV) plays an essential role in viral lytic replication by providing DNA processivity activity to the viral DNA polymerase (ORF9). ORF59 forms a homodimer in the cytoplasm and binds and translocates ORF9 into the nucleus, where it secures ORF9...

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Hlavní autoři: McDowell, Maria E., Purushothaman, Pravinkumar, Rossetto, Cyprian C., Pari, Gregory S., Verma, Subhash C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3700218/
https://ncbi.nlm.nih.gov/pubmed/23678174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03460-12
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