Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development

Directed differentiation from human pluripotent stem cells (hPSCs) has seen significant progress in recent years. Most differentiated populations, however, exhibit immature properties of an early embryonic stage, raising concerns about their ability to model and treat disease. Here, we report the di...

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Main Authors: Nicholas, Cory R., Chen, Jiadong, Tang, Yunshuo, Southwell, Derek G., Chalmers, Nadine, Vogt, Daniel, Arnold, Christine M., Chen, Ying-Jiun J., Stanley, Edouard G., Elefanty, Andrew G., Sasai, Yoshiki, Alvarez-Buylla, Arturo, Rubenstein, John L.R., Kriegstein, Arnold R.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699205/
https://ncbi.nlm.nih.gov/pubmed/23642366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.04.005
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