Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells

Human embryonic (hESCs) and induced pluripotent stem cells (hiPSCs) have been shown to differentiate into primordial germ cells (PGCs) but not into spermatogonia nor haploid spermatocytes or spermatids. Here we show that hESCs and hiPSCs differentiate directly into advanced male germ cell lineages i...

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Detalhes bibliográficos
Main Authors: Easley, Charles A., Phillips, Bart T., McGuire, Megan M., Barringer, Jennifer M., Valli, Hanna, Hermann, Brian P., Simerly, Calvin R., Rajkovic, Aleksander, Miki, Toshio, Orwig, Kyle E., Schatten, Gerald P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698576/
https://ncbi.nlm.nih.gov/pubmed/22921399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.07.015
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