In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

BACKGROUND: Drug-induced liver injury (DILI) is one of the most common adverse reactions leading to product withdrawal post-marketing. Recently, genome-wide association studies have identified a number of human leukocyte antigen (HLA) alleles associated with DILI; however, the cellular and chemical...

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Detalhes bibliográficos
Main Authors: Alfirevic, Ana, Gonzalez-Galarza, Faviel, Bell, Catherine, Martinsson, Klara, Platt, Vivien, Bretland, Giovanna, Evely, Jane, Lichtenfels, Maike, Cederbrant, Karin, French, Neil, Naisbitt, Dean, Park, B Kevin, Jones, Andrew R, Pirmohamed, Munir
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698530/
https://ncbi.nlm.nih.gov/pubmed/22732016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm350
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