The Emerging Role of D-2-Hydroxyglutarate as an Oncometabolite in Hematolymphoid and Central Nervous System Neoplasms

Approximately 20% of unselected cases and 30% cytogenetically diploid cases of acute myeloid leukemia (AML) and 80% of grade II–III gliomas and secondary glioblastomas carry mutations in the isocitrate dehydrogenase (IDH) 1 and 2 genes. IDH1/2 mutations prevent oxidative decarboxylation of isocitrat...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Rakheja, Dinesh, Medeiros, L. Jeffrey, Bevan, Scott, Chen, Weina
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2013
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698461/
https://ncbi.nlm.nih.gov/pubmed/23847760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00169
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars