Interferon-α (IFN-α) suppresses HTLV-1 gene expression and cell cycling, while IFN-α combined with zidovudin induces p53 signaling and apoptosis in HTLV-1-infected cells

BACKGROUND: Human T-cell leukemia virus type-1 (HTLV-1) is the causative retrovirus of adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 gene expression is maintained at low levels in vivo by unknown mechanisms. A combination therapy...

Full description

Saved in:
Bibliographic Details
Main Authors: Kinpara, Shuichi, Kijiyama, Mami, Takamori, Ayako, Hasegawa, Atsuhiko, Sasada, Amane, Masuda, Takao, Tanaka, Yuetsu, Utsunomiya, Atae, Kannagi, Mari
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698133/
https://ncbi.nlm.nih.gov/pubmed/23688327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-52
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items